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- HLA forms part of the Major Histocompatibility Complex (MHC)
- MHC antigens are integral for normal functioning of the immune response.
- Essential role of HLA antigens lies in recognizing self-antigens for protection against micro-organisms and surveillance.
- HLA typing is essential to the rejection that occurs during organ transplantation, and hematopoietic stem cell transplantation.
- Found on the short arm of chromosome 6
- Classified as HLA class I, class II, class III
- Class I (HLA-A, B, C etc) & Class II (HLA-DR, DQ, DP etc): Important roles in immune recognition
- Class III : Coding in same region as class I & II, but may not be important in transplantation
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